The distinction between game-changer weight reduction medicine semaglutide, tirzepatide, and liraglutide

  • Folks had been discovered to lose virtually 16% of their physique weight on the drug tirzepatide in a trial.
  • Producer Eli Lilly stated it hopes the FDA will approve the drug for weight reduction this yr.
  • If authorized, it’ll be a part of buzzy weight reduction drug semaglutide available on the market.

Diabetes drug tirzepatide has been proven to assist individuals lose virtually 16% of their physique weight in a scientific trial, and it might quickly be a part of semaglutide and liraglutide within the ranks of buzzy weight reduction medicines available on the market.

The trial that happened over 72 weeks concerned 938 sufferers with kind 2 diabetes who had been obese or overweight, drugmaker Eli Lilly stated in a press launch on Thursday.

Those that took tirzepatide misplaced 15.7%, or 34.4 kilos, of physique weight on common when in comparison with these on a placebo, who misplaced 3.3% of their weight, or 7 kilos, on common. The contributors weighed 222 kilos on common initially of the trial. 

In response to the press launch, Eli Lilly plans to finish its submission to the FDA within the coming weeks for the drug to be authorized for weight reduction, which it hopes will occur late this yr.

If authorized, tirzepatide would be a part of different buzzy “game-changer” medicine together with semaglutide, which is marketed as Ozempic for diabetes and Wegovy for weight reduction, and liraglutide, which is marketed as Saxenda for weight problems and diabetes.

Semaglutide has develop into so fashionable there have been shortages, as rumors swirl round which celebrities could also be utilizing it. 

These medicine are a part of a household of medicines often known as GLP-1 agonists, which mimic a hormone launched once we eat meals. In addition to serving to the physique to create extra insulin, they scale back the quantity of sugar the liver makes, scale back urge for food, and decelerate the digestion course of.

Widespread negative effects of GLP-1 agonists embrace nausea, diarrhea, abdomen pains, constipation, lowered urge for food, low blood sugar, and complications.

Dr. M. Regina Castro of the Mayo Clinic wrote in an article for the establishment’s web site that it isn’t but sure why GLP-1 agonists assist with weight reduction, however they do curb starvation and might make an individual eat much less. 

Here is how the medicine examine. 


Developed and manufactured by Novo Nordisk, semaglutide is a weekly injection that was authorized by the FDA to deal with kind 2 diabetes below the identify Ozempic in December 2017.

Nonetheless, a trial revealed within the New England Journal of Medication in 2021 involving virtually 2,000 individuals throughout 16 international locations discovered that in 68 weeks, contributors misplaced 15% of their physique weight on common on semaglutide, paving the way in which for it for use as a weight reduction drug.

On the time, Dr. Robert F. Kushner, lead writer of the examine and an weight problems researcher at Northwestern College Feinberg Faculty of Medication who works with Novo Nordisk, referred to as the drug a “game-changer” in an interview with The New York Instances.

“That is the beginning of a brand new period of efficient therapies for weight problems,” he stated.

In June 2021, semaglutide was authorized by the FDA as a once-weekly weight reduction shot below the identify Wegovy for adults who had been both obs ese or obese with a minimum of one weight-related situation, resembling hypertension, kind 2 diabetes, or excessive ldl cholesterol. In December 2022 it was authorized for these aged 12 and up with the identical situations.


Tirzepatide was authorized by the FDA for adults with diabetes in Might 2022, below the identify Mounjaro.

Like semaglutide merchandise, tirzepatide is used to regulate blood sugar ranges, and is run through a weekly injection. Not like semaglutide, it mimics the GIP hormone in addition to GLP-1.

Folks have been discovered to lose giant quantities of weight on the drug in trials, however it isn’t authorized by the FDA for this function.

Along with the trial outcomes launched on April 27, a scientific trial revealed within the New England Journal of Medication final yr confirmed that sufferers who had been overweight or obese and had different well being situations resembling hypertension, excessive ldl cholesterol, or heart problems misplaced 20% of their physique weight in 16 months whereas taking the utmost dose of 15mg. That probably makes it extra highly effective than semaglutide for weight reduction.


Novo Nordisk additionally manufactures liraglutide, which is marketed as Saxenda.

Saxenda was authorized by the FDA in December 2014 for weight administration for adults who’re obese or overweight with a weight-related situation. In April 2020, the drug was authorized for these aged 12 and over, too.

Its results are much less important than different medicine, with individuals shedding between 4 to six kilograms or 5 to 10% of their physique weight, in keeping with a 2017 evaluation.

Throughout a trial, one affected person died by suicide so sufferers must also be monitored for melancholy and suicidal ideas whereas taking it, in keeping with the FDA.